Quick question about ODIN and MDK.

I've had my S4 for 2 years now and not once have I ever ODIN back to stock and re-rooted. I'm thinking of doing this only because I have flashed so many ROMs that I feel like a ODIN might clean up some left over files. My question is, will this help at all? I know doing a full wipe clears the sdcard and other things, but what about the root folder? See picture attached.
Attachment 3437087

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