OTA Sideloading while Rooted

Hi,

I remember reading somewhere that updates after Lollipop would check the entire system image as one block and wouldn't update if it didn't match meaning that the smallest change (like Rooting) would render the device unable to accept OTA updates.

My question is does this only apply if I try to update the device from the notification or would this apply if I tried to sideload the update? ~ Can I update a rooted device by sideloading the update?

Just to be on the safe side: My idea of sideloading an update is downloading the update via the notification, copying it from the device to the PC, booting into (stock) recovery and choosing sideload update.

Thanks